On July 1 he inoculated the boy again, and no smallpox developed in 1904 the opening ceremony for the first Olympic Games to be held in the US took place in St Louis, Missouri. Jamestown’s economy began to thrive after the introduction of a new type of tobacco in 1796 the physician Edward Jenner scratched fluid from a cowpox blister into the skin of an eight-year-old boy. In 1264 the English barons under Simon de Montford defeated Henry III at the battle of Lewes in 1607 the first permanent English settlement in America was established at Jamestown, Virginia, by a group of about 100 Virginia Company settlers.